ABSTRACT
The major underlying pathology in chronic granulomatous disease is a primary defect in membranous oxidase of phagocytic cells. Affected patients suffer from recurrent cutaneous and visceral abscess formation by catalase positive micro-organisms. The other characteristic features of the disease are granulomas in gastrointestinal, respiratory and urinary tracts. In this study we review the natural course of the disease in a 12 year old boy. He had a violaceous chronic granuloma on his nose since 7 yr of age. Recently the redness of his eyes and photophobia has been worsened. An ophthalmologic consultaion confirmed a chronic keratitis, and ultimately immunological and bacteriological tests coupled with a pathology specimen documented the diagnosis of chronic granulomatosis. With appropriate treatment, the clinical symptomatology of the child improved